Unlike traditional LNPs, targeted LNPs introduce additional layers of analytical, process, and CMC complexity due to surface-bound ligands and multi-step modifications. This workshop will examine how to align analytical development with process development and scale-up strategies to manage this complexity, ensure high product quality, and enable reliable manufacturing.

This workshop will gather experts to discuss:

• Unlocking advanced analytics for tLNPs to quantify conjugated binders, assess particle heterogeneity, and confirming ligand integrity following large-scale manufacturing
• De-risking batch-to-batch variability and maintaining CQA consistency by designing conjugation chemistry and manufacturing processes achieving uniform ligand attachment
• Navigating scale-up of tLNPs by addressing added downstream, analytical, and stability of targeting challenges not seen with traditional LNPs