Engineering Single-Component Homogenous Amphiphilic Routed Particles (SHARP) to Program Organ Tropism
- Introduce a SHARP platform that enables efficient nucleic acid delivery without multicomponent formulation complexity
- Demonstrate programmable organ tropism achieved through molecular-level control of amphiphilic structure, enabling selective delivery to organs such as liver, lung, spleen, and the lymphatic system etc
- Highlight the translational potential and future directions of this platform for organ-selective nucleic acid therapeutics across diverse disease indications