Enhancing Cytosolic Delivery of Lipid Nanoparticle Payloads Using Peptides

• Incorporating peptides in LNPs had minimal impact on particle properties and showed improved intracellular delivery of mRNA
• The presence of peptides in LNPs did not change particle biodistribution in vivo
• Peptide-LNPs showed higher mRNA delivery in most organs vs LNP control

Speakers:

Soultan Al-Halifa

Director, Research & Development, Biopharmaceutical Chemistry

Feldan Therapeutics