Evaluating PEG-Alternative LNPs for Extrahepatic Delivery in In Vivo Cell Reprogramming
- Novel Ionizable Lipid: Demonstrates enhanced T-cell tropism with reduced hepatic uptake
- In Vivo Characterization: Ongoing studies on biodistribution, safety, and toxicity profiles
- Formulation Strategy: Assessing PEG-alternatives in combination with ionizable lipids for delivery feasibility