Payload Delivery Tool Kit: Lipids vs Polymers
- Compare lipid and polymeric nanoparticle platforms with a specific focus on extra hepatic payload delivery
- Differences in biodistribution, cellular uptake, endosomal escape, payload compatibility, repeat dosing, and translational readiness
- Highlight why extrahepatic delivery remains challenging for lipid nanoparticles and where polymeric systems may offer advantages, as well as the trade-offs involved in moving beyond clinically validated lipid platforms