Atip Lawanprasert
Postdoctoral Fellow, Murthy Lab University of California at Berkeley
Seminars
Wednesday 3rd June 2026
Panel Discussion: Delving into Advanced High Throughput LNP Screening Platforms to Accelerate Lead Discovery, Enhance Target Selection, & Improve Extrahepatic Delivery Success
9:30 am
- How to optimize screening approaches to rapidly evaluate large libraries of LNP compositions and identify candidates with enhanced extrahepatic tropism?
- What screening approaches are most effective for selecting and testing targeting moieties to ensure high specificity, manufacturability, and reproducible performance after LNP conjugation?
- How can AI/ML and predictive models be integrated into experimental screening workflows to improve lipid and ligand selection?
Wednesday 3rd June 2026
High-Throughput Screening of Charge Switchable Lipids Discovers NonReactogenic LNPs with Extrahepatic Tropism
10:15 am
- We develop a new high-throughput screening strategy that can screen LNP libraries and accurately predict delivery in vivo directly from tissue sequencing
- Our strategy can screen LNPs in organs that traditional screening methods are impractical, such as the heart, kidneys, and brain
- We use our strategy to screen a new class of lipids to identify LNPs with extrahepatic tropisms and low reactogenicity
