James Carroll
President & Chief Scientific Officer RNA Nanobiotics
Seminars
Thursday 4th June 2026
Targeted Therapeutic Delivery Using Programmable RNA Architectures for Oncology Indications
3:30 pm
- Programmable RNA architectures maintains defined structural integrity in circulation, enabling precise molecular targeting and controlled payload presentation across therapeutic modalities
- Preclinical biodistribution studies demonstrate minimal nonspecific uptake, with little to no detectable accumulation in the liver and rapid renal clearance of unbound material when target engagement does not occur
- Complementary RNA nanostructure and RNA-programmed vesicular systems can be selectively deployed based on biological constraints and uptake requirements, supporting targeted delivery beyond conventional lipid-based approaches
