Ketaki Deshmukh
Senior Scientist Novo Nordisk
I am a senior scientist at Novo Nordisk and working on novel lipid screening for extrahepatic delivery. I leverage my PhD in multidisciplinary areas of chemistry, nanotechnology, and pharmaceuticals to develop innovative formulations of lipid nanoparticles (LNPs) for gene delivery under GMP/GLP standards. With more than eight years of experience in the field, I have a track record of creating novel methodologies and products, demonstrated by publishing patents and multiple peer-reviewed papers.
Seminars
Unlike traditional LNPs, targeted LNPs introduce additional layers of analytical, process, and CMC complexity due to surface-bound ligands and multi-step modifications. This workshop will examine how to align analytical development with process development and scale-up strategies to manage this complexity, ensure high product quality, and enable reliable manufacturing.
This workshop will gather experts to discuss:
- Unlocking advanced analytics for tLNPs to quantify conjugated binders, assess particle heterogeneity, and confirming ligand integrity following large-scale manufacturing
- De-risking batch-to-batch variability and maintaining CQA consistency by designing conjugation chemistry and manufacturing processes achieving uniform ligand attachment
- Navigating scale-up of tLNPs by addressing added downstream, analytical, and stability of targeting challenges not seen with traditional LNPs
