Sanjib Saha
Senior Scientist, Advanced Drug Delivery AstraZeneca
Seminars
Wednesday 3rd June 2026
Panel Discussion: Delving into Advanced High Throughput LNP Screening Platforms to Accelerate Lead Discovery, Enhance Target Selection, & Improve Extrahepatic Delivery Success
9:30 am
- How to optimize screening approaches to rapidly evaluate large libraries of LNP compositions and identify candidates with enhanced extrahepatic tropism?
- What screening approaches are most effective for selecting and testing targeting moieties to ensure high specificity, manufacturability, and reproducible performance after LNP conjugation?
- How can AI/ML and predictive models be integrated into experimental screening workflows to improve lipid and ligand selection?
Tuesday 2nd June 2026
Designing Robust Analytics & Scalable Processes for Targeted LNPs to Achieve High Quality, Consistent Manufacturing for Clinical Readiness
1:00 pm
Unlike traditional LNPs, targeted LNPs introduce additional layers of analytical, process, and CMC complexity due to surface-bound ligands and multi-step modifications. This workshop will examine how to align analytical development with process development and scale-up strategies to manage this complexity, ensure high product quality, and enable reliable manufacturing.
This workshop will gather experts to discuss:
- Unlocking advanced analytics for tLNPs to quantify conjugated binders, assess particle heterogeneity, and confirming ligand integrity following large-scale manufacturing
- De-risking batch-to-batch variability and maintaining CQA consistency by designing conjugation chemistry and manufacturing processes achieving uniform ligand attachment
- Navigating scale-up of tLNPs by addressing added downstream, analytical, and stability of targeting challenges not seen with traditional LNPs
