Soultan Al-Halifa
Director Feldan Therapeutics
Seminars
Thursday 4th June 2026
Panel Discussion: Exploring Next-Generation Nanoparticle Systems Beyond LNPs to Expand Extrahepatic Targeting, Improve Safety, & Enable Broader Therapeutic Delivery
9:30 am
- Where do LNPs begin to show limitations for extrahepatic delivery and which emerging delivery vehicles offer the most realistic advantages?
- How do alternative delivery platforms compare in terms of manufacturability, scalability, safety, and regulatory readiness when moving towards the clinic?
- Which delivery challenges, from immunogenicity to targeting specificity, are best addressed by exploring non-LNP platforms, and where do LNPs remain the most practical solution?
Thursday 4th June 2026
Enhancing Cytosolic Delivery of Lipid Nanoparticle Payloads Using Peptides
11:30 am
- Incorporating peptides in LNPs had minimal impact on particle properties and showed improved intracellular delivery of mRNA
- The presence of peptides in LNPs did not change particle biodistribution in vivo
- Peptide-LNPs showed higher mRNA delivery in most organs vs LNP control
