High-Throughput Screening of Charge Switchable Lipids Discovers NonReactogenic LNPs with Extrahepatic Tropism

• We develop a new high-throughput screening strategy that can screen LNP libraries and accurately predict delivery in vivo directly from tissue sequencing
• Our strategy can screen LNPs in organs that traditional screening methods are impractical, such as the heart, kidneys, and brain
• We use our strategy to screen a new class of lipids to identify LNPs with extrahepatic tropisms and low reactogenicity

Speakers:

Atip Lawanprasert

Postdoctoral Fellow, Murthy Lab

University of California at Berkeley