8:45 am Registration & Welcome Coffee
9:25 am Chair’s Opening Remarks
Engineering Clinically Translatable Lipid Carriers
9:30 am Advancing Lipid-Based Delivery Systems: From Discovery to the Clinic
Synopsis
- Addressing bottlenecks to bring lipid-based delivery systems to reality for genetic therapy pipelines – sharing insights from Osteopetrosis & Corneal Dystrophy siRNA delivery pipeline
- Overcoming LNP-related delivery challenges to engineer vehicles for extrahepatic delivery
- Delivery vehicle and route of administration considerations for localized delivery and ensuring payload stability
10:00 am Modifying Formulations: Effective Animal Model Study Design
Synopsis
- Characterization of lipid-based platform for organ targeting
- Animal model strategies for better accuracy in platform performance
- Translating in vitro and mouse model data findings to support safe and effective extrahepatic delivery translatability
10:30 am Morning Networking Break
11:15 am Stability Considerations for mRNA-LNP Drug Development
Synopsis
- When should we consider stability in development?
- Sharing approaches for incorporating stability considerations into process development
11:45 am Robotic Synthesis for GMP Manufacturing of Next-Gen Lipid-Based Delivery Vehicles – Insights to Support Early Excipient & Formulation Decision Making
Synopsis
- Forward planning for manufacturing lipid-delivery technologies for clinical programs
12:15 pm Lunch Break
Synopsis
Take this chance to meet the expert speakers, connect with your peers and explore our exhibition booths
Design & Evaluation of Novel Lipid-Delivery Constructs Tailored to Your Program
1:30 pm Machine Learning-Driven Design of Bespoke Vehicles for Gene Therapy Payloads
Synopsis
- Impact of nanoparticle structure, size, and physical characteristics on tissue-specific delivery
- Demonstrate how nanoparticle attributes can be tuned via machine learning based on payload type
- Discuss how ML-driven nanoparticle design can be leveraged to influence delivery to different tissues
2:00 pm Panel Discussion: Looking into the Future: The Next Wave of Lipid-Based Nanocarrier Development
Synopsis
- Why is it important we, as a collective, ensure we’re keeping in-step with the latest nanocarrier constructs
- What are the critical challenges we’re not addressing in full to progress more candidates through to the clinic leveraging lipid-delivery means?
- What are the avoidable challenges developers can find they encounter in nanocarrier decision making?
2:45 pm Afternoon Break
Synopsis
Grab a coffee and explore our exhibition booths, networking and more!
3:15 pm Extending Our Armamentarium – Physiologically-Targeted Intracellular Delivery Using Phosphatidylserine
Synopsis
- The LNC (Lipid Nano-Crystal) delivery platform – what it potentially adds to the current landscape of lipid-based nanoparticle delivery
- The complex physiology of phosphatidylserine in lipid membranes – as both surface marker for efferocytotic clearance and as an active contributor to membrane fusion
- In vitro and in vivo experience to date with the LNC platform – putting theory to the test
3:45 pm Optimizing Lipid Nanoparticles Formulation and Improving their Stability by Lyophilization
Synopsis
- Optimizing the lipid nanoparticle formulation for mRNA delivery with DOE approach
- Evaluating how different cargoes can affect LNP stability
- Developing a lyophilized formulation for long-term storage of LNP