8:45 am Registration & Welcome Coffee

9:25 am Chair’s Opening Remarks

  • Haishan Li Director - Chemistry, Hopewell Therapeutics

Engineering Clinically Translatable Lipid Carriers

9:30 am Advancing Lipid-Based Delivery Systems: From Discovery to the Clinic


  • Addressing bottlenecks to bring lipid-based delivery systems to reality for genetic therapy pipelines – sharing insights from Osteopetrosis & Corneal Dystrophy siRNA delivery pipeline
  • Overcoming LNP-related delivery challenges to engineer vehicles for extrahepatic delivery
  • Delivery vehicle and route of administration considerations for localized delivery and ensuring payload stability

10:00 am Modifying Formulations: Effective Animal Model Study Design

  • Haishan Li Director - Chemistry, Hopewell Therapeutics


  • Characterization of lipid-based platform for organ targeting
  • Animal model strategies for better accuracy in platform performance
  • Translating in vitro and mouse model data findings to support safe and effective extrahepatic delivery translatability

10:30 am Morning Networking Break

11:15 am Stability Considerations for mRNA-LNP Drug Development

  • Ami Jo Senior Process Engineer, Omega Therapeutics


  • When should we consider stability in development?
  • Sharing approaches for incorporating stability considerations into process development

11:45 am Robotic Synthesis for GMP Manufacturing of Next-Gen Lipid-Based Delivery Vehicles – Insights to Support Early Excipient & Formulation Decision Making

  • Hesong Han Professor, University of California, Berkeley


  • Forward planning for manufacturing lipid-delivery technologies for clinical programs

12:15 pm Lunch Break


Take this chance to meet the expert speakers, connect with your peers and explore our exhibition booths

Design & Evaluation of Novel Lipid-Delivery Constructs Tailored to Your Program

1:30 pm Machine Learning-Driven Design of Bespoke Vehicles for Gene Therapy Payloads


  • Impact of nanoparticle structure, size, and physical characteristics on tissue-specific delivery
  • Demonstrate how nanoparticle attributes can be tuned via machine learning based on payload type
  • Discuss how ML-driven nanoparticle design can be leveraged to influence delivery to different tissues

2:00 pm Panel Discussion: Looking into the Future: The Next Wave of Lipid-Based Nanocarrier Development


  • Why is it important we, as a collective, ensure we’re keeping in-step with the latest nanocarrier constructs
  • What are the critical challenges we’re not addressing in full to progress more candidates through to the clinic leveraging lipid-delivery means?
  • What are the avoidable challenges developers can find they encounter in nanocarrier decision making? 

2:45 pm Afternoon Break


Grab a coffee and explore our exhibition booths, networking and more!

3:15 pm Extending Our Armamentarium – Physiologically-Targeted Intracellular Delivery Using Phosphatidylserine


  • The LNC (Lipid Nano-Crystal) delivery platform – what it potentially adds to the current landscape of lipid-based nanoparticle delivery
  • The complex physiology of phosphatidylserine in lipid membranes – as both surface marker for efferocytotic clearance and as an active contributor to membrane fusion
  • In vitro and in vivo experience to date with the LNC platform – putting theory to the test

3:45 pm Optimizing Lipid Nanoparticles Formulation and Improving their Stability by Lyophilization


  • Optimizing the lipid nanoparticle formulation for mRNA delivery with DOE approach
  • Evaluating how different cargoes can affect LNP stability
  • Developing a lyophilized formulation for long-term storage of LNP

4:15 pm Chair’s Closing Remarks & End of Summit