Elucidating & Overcoming PEG-Directed Immunity Against PEGylated LNPs
Time: 12:15 pm
day: Conference Day Two
Details:
- What is the prevalence and magnitude of pre-existing immunity against polyethylene glycol (PEG), a polymer used in vast majority of LNP formulations?
- Clinical evidence on LNP-induction of anti-PEG antibodies (APA), and impact on LNP medications
- Methods to overcome pre-existing APA and mitigate PEG-specific immunogenicity and hypersensitivity
