Engineering HDT Bio’s Thermostable LION/repRNA Lyophilized Vaccine to Increase Accessibility & Enable Localized Distribution
Time: 9:45 am
day: Conference Day Two
Details:
- Engineering HDT Bio’s non-LNP-based LION/repRNA lyophilized vaccine stored at 2-8°C and 25°C, facilitating practical storage and distribution, particularly in low resource settings
- Comprehensive screening of mono- and disaccharides (e.g., sucrose, trehalose, maltose) as lyoprotectants for the lyophilized vaccine, assessing their impact on particle size, repRNA integrity, and in vitro potency post-lyophilization
- Evaluation of in vivo biodistribution and efficacy of the LION/repRNA vaccine