Redefining Nanoparticle Delivery: PEG-Free LNP Formulation for Targeted & Extrahepatic Applications
Time: 1:45 pm
day: Conference Day Two
Details:
- Replacing PEG lipids with natural gangliosides to mitigate immune responses, lower toxicity and improve the overall safety of nanoparticle delivery systems
- Enabling targeted delivery to bone marrow, lungs and other non-hepatic tissues and cells without the need for antibody conjugation, overcoming key translational hurdles
- Characterizing particle size, encapsulation efficiency and in vitro/in vivo performance to drive enhanced transfection, biodistribution and therapeutic impact
