Roundtable Discussion: Addressing Challenges in Animal Models for Translatable LNP Development

Time: 2:00 pm
day: Conference Day One


  • Unraveling the discrepancies between animal models and human responses in LNP delivery, confronting the challenges of species-specific variations in physiology and metabolism
  • Developing innovative strategies to enhance the predictive value of animal models, acknowledging limitations and implementing adjustments for a more accurate reflection of human LNP delivery dynamics
  • Exploring the incorporation of human-relevant elements in preclinical studies, from utilizing humanized models to embracing in vitro systems, to foster more reliable predictions of LNP behavior and efficacy in clinical settings