The Endosomal Escape Vehicle Platform Enhances Lipid Nanoparticle-Mediated Delivery of Genomic Medicines
Time: 3:45 pm
day: Conference Day Two
Details:
- Lipid nanoparticle (LNP) technology is promising for delivering nucleic acid therapeutics like mRNA vaccines and gene editing tools. Despite challenges such as limited tissue targeting and low delivery efficiency, our proprietary Endosomal Escape Vehicle (EEV™) technology enhances LNP delivery of genomic medicines.
- Our research shows that EEV-modified LNPs (EEV-LNPs) greatly enhance mRNA delivery and gene editing efficacy compared to standard LNPs in vitro. Through mechanistic studies, we’ve elucidated EEV-LNP’s uptake mechanism, revealing its ability to target diverse cell types and tissues. These findings underscore the potential of our EEV-LNP platform for enhancing genomic medicine delivery, particularly in mRNA and gene editing applications.
