Workshop A – Enhancing the Precision of Lipid-Based Delivery Systems Through Conjugation & Active Targeting to Unlock Effective Therapeutic Delivery to Novel Organs & Tissues
Time: 9:00 am
day: Pre-Conference Workshop Day
Details:
Manipulating the tropism of your delivery system via targeting systems is a promising approach to improve the precision and efficacy of lipid-based delivery systems. However, it presents new challenges including lipid and conjugation chemistry, CMC complexities, in vitro to in vivo translatability, promoting endosomal escape and avoiding accumulation in the liver. This workshop will focus on designing and optimizing active targeting systems that translate seamlessly from research to clinical applications, ensuring robust delivery to desired cells and tissues.
Key Takeaways:
- Overcoming challenges like bio and chemical conjugation chemistry, receptor uptake, endosomal escape, and avoiding the liver to achieve precise delivery and enhance therapeutic effect
- Manipulating your lipid tropism using composition, ratios, shape and nanoparticle structure to deliver your payload to the desired organ, tissue or cell type
- Fine-tuning the tropism and profiles of delivery systems to achieve translatability from in vitro to in vivo systems and ensure maximum efficacy in humans
