Angelo Amabile

Company: Mount Sinai Health System

Job title: Assistant Professor

Seminars:

Bispecific Antibody-Mediated Targeting of Lipid Nanoparticles for Precision RNA Delivery 1:15 pm

Implementing innovative LNP targeting strategies using bispecific antibodies to confer cell specificity, enhancing RNA uptake while minimizing off-target effects, thereby optmizing therapeutic efficacy Validating cell-specific RNA delivery through functional assays and in vivo models, confirming the potential of bispecific antibody-guided LNPs for next-generation RNA therapeutics  Engineering lipid nanoparticle (LNP) formulations for efficient and selective RNA…Read more

day: Conference Day One

Workshop A – Enhancing the Precision of Lipid-Based Delivery Systems Through Conjugation & Active Targeting to Unlock Effective Therapeutic Delivery to Novel Organs & Tissues 9:00 am

Manipulating the tropism of your delivery system via targeting systems is a promising approach to improve the precision and efficacy of lipid-based delivery systems. However, it presents new challenges including lipid and conjugation chemistry, CMC complexities, in vitro to in vivo translatability, promoting endosomal escape and avoiding accumulation in the liver. This workshop will focus…Read more

day: Pre-Conference Workshop Day