Pre-Conference Workshop Day
Tuesday, June 24
Workshop places are limited to ensure the best learning experience, secure your place today.
8:00 am Light Breakfast & Check-In
9:00 am Workshop A – Enhancing the Precision of Lipid-Based Delivery Systems Through Conjugation & Active Targeting to Unlock Effective Therapeutic Delivery to Novel Organs & Tissues
Synopsis
Manipulating the tropism of your delivery system via targeting systems is a promising approach to improve the precision and efficacy of lipid-based delivery systems. However, it presents new challenges including lipid and conjugation chemistry, CMC complexities, in vitro to in vivo translatability, promoting endosomal escape and avoiding accumulation in the liver. This workshop will focus on designing and optimizing active targeting systems that translate seamlessly from research to clinical applications, ensuring robust delivery to desired cells and tissues.
Key Takeaways:
- Overcoming challenges like bio and chemical conjugation chemistry, receptor uptake, endosomal escape, and avoiding the liver to achieve precise delivery and enhance therapeutic effect
- Manipulating your lipid tropism using composition, ratios, shape and nanoparticle structure to deliver your payload to the desired organ, tissue or cell type
- Fine-tuning the tropism and profiles of delivery systems to achieve translatability from in vitro to in vivo systems and ensure maximum efficacy in humans
12:00 pm Lunch Break & Networking
1:00 pm Workshop B – Innovating Lipid & Polymer Chemistry with AI to Navigate the Design Space & Revolutionize Delivery Systems for Precision & Scalability
Synopsis
The vast design space available for lipid and polymer-based delivery systems expanded by the variability in chemistry and nanoparticle compositions presents challenges in creating tailored nanoparticles. This workshop will delve into how innovations in lipid and polymer chemistry, and computational screening can streamline this complexity. Thus, enabling the discovery of nanoparticles with properties optimized for specific modalities, diseases, and organs. Participants will explore strategies to develop “programmable” nanoparticles for more precise and efficient therapeutic delivery.
Key Takeaways
- Streamlining the vast design space of lipid and polymer nanoparticles by identifying optimal combinations, ratios and structures tailored for specific therapeutic applications
- Utilizing AI-driven computational screening to predict nanoparticle properties, cut down noise from impurities and accelerate the discovery of next-gen delivery systems
- Engineering modality-specific LNP platforms with properties fine-tuned for targeted delivery to specific diseases, organs or tissues
- Optimizing structure-function relationships to create reliable, translatable and clinically compliant delivery systems for therapeutic success