Pre-Conference Workshop Day
Tuesday, July 19 | 9:30am - 3:30pm
9.00 - 11.30
Exploring Lipid Chemistry & Nanoparticle Surface Modification for Enhanced Cytosolic Delivery
With the surge of lipid-based nanoparticles being developed, the influence of lipid chemistry and formulation on the delivery of your cargo is crucial to consider.
Compare the influence of different lipid chemical structures and surface modification of lipid nanoparticle on endosomal escape, gene silencing, distribution and cytosolic delivery to ensure safe and efficacious delivery of your novel therapeutic.
University of Connecticut
12.30 - 2.30
Enabling Organ & Cell Targeted Delivery
Targeting extrahepatic tissues is the key next step for lipid-based delivery to continue maximizing therapeutic potential and allowing treatment of unmet patient needs.
However, due to trafficking to and accumulation in the liver, this is easier said than done.
Join this workshop to hear:
- Latest research and strategies to achieve targeted delivery to organs and cells
- Lesson learned from mRNA case study and applying for future payloads and modalities
- Exploit the potential of synthetic biodegradable lipids
Founder & Chief Executive Officer
3.00 - 5.30
Developing Robust & Reliable Reference Materials, Documentary Standards & Standard Test Methods for Enhanced Lipid-Based Nanoparticle Innovation
Lipid-based nanoparticles have the potential to drastically improve the delivery of novel and emerging therapeutics. However, in order to continue the advancement of these next generation delivery vehicles, there is a need for reliable and robust reference materials and documentary standards.
Development of suitable reference materials will facilitate measurement assurance, method development and technology innovation in this rapidly expanding field. Documentary standards and standard test methods will help speed up the regulatory submission and review process enabling high quality therapeutics to reach the market faster.
Join this workshop to understand the ongoing work to develop reference materials, documentary standards and standard test methods for moving innovative LNP delivery platforms forward. Delve into the characterization of physicochemical and biological quality attributes such as stability, size, chemical design and release mechanism to ultimately enhance innovation.
Certified Reference Materials for Lipid-Based Nano-Delivery Systems – Development & Unique Challenges
Through the Innovative Solutions Canada program, the National Research Council of Canada (NRC) and Integrated Nanotherapeutics Inc. (INT) are working together to develop stable drug carrier formulations, in order to support the development of drug product submissions, streamline the regulatory approval process and improve the manufacturability of drug delivery formulations.
Six formulations of liposomes and lipid nanoparticles (LNP) using INT’s proprietary scaffold lipid technology have been produced with three different sizes and three different surface charges (neutral, positive or negative). The size, polydispersity and zeta potential of each formulation were characterized by dynamic light scattering.
Formulations were prepared at a specific concentration in the presence of sucrose for long term storage at -70 °C. Shan will discuss the viability profiles of these formulations tested in vitro. Strategies and challenges to improve the stability and reduce the variability of formulations will also be mentioned.
Staff Research Chemist
National Institute of Standards & Technology
Dr. Shan Zou
Senior Research Officer, Team Leader for Nanoscale Measurement Disciplines; Adjunct Professor of Chemistry
Metrology Research Centre of the National Research Council Canada (NRC); Carleton University